Microbial Pathogenesis & Infectious Diseases

Antimicrobial Resistance and its Consequences

The antimicrobial resistance crisis is the increasing global incidence of infectious diseases affecting the human population, which are fatal with any known antimicrobial agent. Three major factors determine this crisis :  The increasing frequency of AMR phenotypes among microbes is an evolutionary response to the widespread use of antimicrobials, the large and globally connected human population allows pathogens in any environment access to all, the extensive use of antimicrobials by humans provides the strong discerning pressure that drives the evolutionary reaction in the microbial world. 

The other two  factors that gets affected, the rate at which antimicrobial resistance as well as virulence factors evolve in microbial world may be slowed down. This may be achieved by radically reducing the global use of current and potential antimicrobials. The legislation of  the use of antimicrobials and to educate the healthcare world,  have not broadly addressed the problem of achieving an overall reduction in the human use of antimicrobials and the  comprehensive education program will be required to change the public model of antimicrobial usage.

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